Flagging the Forgetting/

Alzbioindigo

02/28/2011

Accelerating the development of New Molecular Bio Markers for Alzheimer's Disease

 

This project aims to develop an Indo-European network to accelerate the development of new molecular biomarkers for Alzheimer’s Disease (AD), in full agreement with the EMEA guidelines (EMEA/CHMP/SAWP/72894/2008 Corr), in coherence with the concept of biomarker “signatures” as followed by PharmaCog IMI project, EuroADNI initiative, supported by French Eurobiomed and Indian Biogenesis clusters. Objectives are to advance harmonisation in research on AD, to strenghtening bilateral S&T cooperation between Europe and India. Specific aims are to: Organize seminars, standardize diagnosis criteria and cognitive evaluation (ADNI battery), Implement and standardize biomarkers (CSF tau, Ptau, Abeta), harmonize ethical principles, identify new biomarkers by detecting a large diversity of proteins in plasma and CSF using state of the art proteomics techniques, to disseminate/exploit. The consortium comprises: An Indian memory Center and pharmacology team (Prof Borgohain, NIMS, Hyderabad), A French excellence research team for biomarkers, specific monoclonal antibody selection for diagnosis, theranostic and prognosis, system biology for multi-scale modelling in complex pathologies (CNRS Sysdiag, Dr Laune, Montpellier) and a French pharmacology team in France, coordinator of IMI PharmaCog (CNRS, INCM , UnivMed, Prof Blin, Marseille), A proteomics centre in Germany for biomarker discovery and validation, using neuroproteomics and bioinformatics (Prof Meyer, Bochum), A Portuguese Neuropharmacology department (Prof Sampaio, Lisbon) for regulatory aspects.

About/

CNRS Université Mediterranée, Marseille

CNRS Université Mediterranée, Marseille
Olivier Blin

CNRS Université Mediterranée, Marseille is a government-funded research organisation, under the administrative authority of France's Ministry of Research. Founded in 1939 by governmental decree it has the missions to evaluate and carry out all research capable of advancing knowledge and bringing social, cultural, and economic benefits for society; to contribute to the application and promotion of research results; to develop scientific information and to support research training. As the largest fundamental research organisation in Europe, CNRS carried out research in all fields of knowledge, through its eight institutes, including Institute of Biological Sciences, and two national institutes CNRS laboratories (or research units) are located throughout France, and employ a large body of tenured researchers, engineers, and support staff. CNRS annual budget represents a quarter of French public spending on civilian research.

 

 

Ruhr-Universität Bochum, Medicine Proteome Centre, Bochum

Ruhr-Universität Bochum, Medicine Proteome Centre, Bochum
Professor. Helmut E. Meyer

Ruhr-University Bochum focuses in the life sciences (medical technology, neuroscience, protein research), plasma physics and technology, and materials science. The Medizinische Proteom-Center (MPC), under the direction of Prof. MEYER, has a special expertise in the analysis of posttranslational protein modifications and biological mass spectrometry, and coordinates the Brain Proteome Initiative (NGFN and HUPO BPP).

MPC offers all state–of–the art techniques (ESI-ITMS, MALDI-TOF/TOF, ESI/MALDI-QTOF, 2D gel lectrophoresis, DIGE, multidimensional–nano-HPLC) and a bioinformatics structure (Dr STEPHAN). Protein biomarkers (Dr STÜHLER) are identified using a proteomics workflow comprising microdissection, label-free proteomics or two-dimensional gel electrophoresis, and immunohistochemistry. Using a protein chips, highly parallel analysis of thousands of proteins in applications such as protein-protein, protein-DNA or protein-ligand interaction studies are performed (E NORDHOFF)

 

University of Lisbon, Clinical Neuropharmacology, Lisbon

University of Lisbon, Clinical Neuropharmacology, Lisbon
Professor Cristina Sampaio

University of Lisbon is a public university in Lisbon, Portugal with 20 000 students, 1300 administrative and 1600 teaching staff. With 11 different faculties including school of Medicine. Research is carried out in Laboratories, in connection with the public and private sectors as well as through exchange programs with other Universities. Major areas of collaboration are Improvement of medical education and Health systems research. The Clinical Neuropharmacology team is headed by Prof. Cristina Sampaio in the Instituto de Medicina Molecular at University of Lisbon.She is Director of the Regional Pharmacovigilance Unit. She is member of the Committee of Proprietary Medicinal products) and of Scientific Advise Working Party (European Medicines Evaluation Agency-EMA). She is co-ordinator Editor of the Movement Disorders Cochrane Review group. Clinical Pharmacology research team experts in developing standards for efficient drug discovery; Bioassay; Biomarker qualification procedures.

 

CNRS, SysDiag, Montpellier

CNRS, SysDiag, Montpellier
Daniel Laune

A joint CNRS laboratory created in 2007, SysDiag is the first laboratory in France to promote research for diagnosing human diseases. The main challenge for SysDiag is to invent the tools needed for diagnosis in the future. Sysdiag is an interdisciplinary structure that relies on Basic research in integrative biology and systems; Platforms advanced technology (monoclonal antibodies, bioinformatics and biostatistics, peptide chemistry, clinical proteomics ...). The major research areas are Identification of new biomarkers and development of specific diagnostic tools for early and differential diagnosis of Alzheimer disease in cerebrospinal fluid and blood, Clinical validation of selected biomarkers using specific immunoassay development in collected samples, Statistical analysis of diagnosis performance of biomarker combination by evaluating diagnosis characteristics (specificity, sensibility and multiple Receiving Operator Characteristics).


Nizam Institute of Medical Sciences

Nizam Institute of Medical Sciences
Prof. Rupam Borgohain

Nizam Institute of Medical Sciences is a 985 bedded hospital with 28 Departments out of them, 16 are Super and Broad Specialties. The average no. of out-patients visiting per day is about 1275, and the no. of in-patients admitted per day is about 80 and is a referral Hospital for more than 250 organisations. NIMS conducts 8 super specialty courses of DM and M.Ch. in the Departments like Cardiology, Neurology, Nephrology, etc recognized by Medical Council of India apart from other para medical courses. More than 412 research projects have been completed by various faculty members with the approval of Ethical Committee. In addition about 3000 Research papers were published in national and international journals since 1989. NIMS has a fully equipped central research lab and animal research lab. Memory Clinic provides world class diagnostic and treatment facilities to AD patients. Dr.Rukmini Heads the memory clinic and Prof.Naidu the Dept. of Pharmacology at NIMS